How does vertical laminar fracture impact the decision-making in thoracolumbar fractures? A systematic scoping review and meta-analysis.

OBJECTIVE: Although vertical laminar fracture (VLF) is generally considered a severity marker for thoracolumbar fractures (TLFs), its exact role in decision-making has never been established. This scoping review aims to synthesize the research on VLF's role in the decision-making of TLFs. METHODS: A systematic review was conducted following PRISMA guidelines. We searched PubMed, Scopus, and Web of Science from inception to  June 11, 2023, for studies examining the association of VLF in thoracolumbar fractures with dural lacerations, neurological deficits, radiographic parameters, or treatment outcomes. Additionally, experimental studies that analyze the biomechanics of burst fractures with VLF were included. The studies extracted key findings, objectives, and patient population. A meta-analysis was performed for the association of VLF with dural laceration and neurological deficit, and ORs were pooled with a 95% confidence interval (CI). RESULTS: Twenty-eight studies were included in this systematic review, encompassing 2021 patients, and twelve were included in the meta-analysis. According to the main subject of the study, the association of VLF with a dural laceration (n = 14), neurological deficit (n = 4), radiographic parameters (n = 3), thoracolumbar fracture classification (n = 2), and treatment outcome (n = 2). Seven studies with a total of 1010 patients reported a significant association between VLF and neurological deficit (OR = 7.35, 95% CI [3.97, 14.25]; P < 0.001). The pooled OR estimates for VLF predicting dural lacerations were 7.75, 95% CI [2.41, 24.87]; P < 0.001). CONCLUSION: VLF may have several important diagnostic and therapeutic implications in managing TLFs. VLF may help to distinguish AO type A3 from A4 fractures. VLF may help to predict preoperatively the occurrence of dural laceration, thereby choosing the optimal surgical strategy. Clinical and biomechanical data suggest VLF may be a valuable modifier to guide the decision-making in burst fractures; however, more studies are needed to confirm its prognostic importance regarding treatment outcomes.

Pediatric retroclival hematomas.

BACKGROUND: Traumatic retroclival hematomas (RCHs) are infrequent occurrences among the pediatric population. The existing body of research pertaining to these hematomas primarily consists of case reports or small case series, which do not provide adequate guidance for managing this condition. OBJECTIVE: This study aims to present a report on four cases of RCHs. Additionally, we aim to conduct a systematic review to consolidate the existing literature on pediatric RCHs. METHODS: The authors conducted a systematic review in accordance with the PRISMA and CARE guidelines. A multivariate logistic regression model was developed to evaluate the potential impact of various clinical variables on clinical outcomes. The study also documented four of our cases, one of which was a rare occurrence of spontaneous subdural RCH. RESULTS: A total of 62 traumatic RCHs have been documented in the literature. We documented three cases of traumatic RCHs and one case of spontaneous RCH. A systematic analysis of 65 traumatic RCHs was performed. Of trauma cases, 64.6% demonstrated craniocervical junction instability with 83.3% ligamentous involvement. Thirty-five patients were males. 50.7% were aged between 5 and 9 years. Cranial nerve palsies occurred in 29 patients (27 had abducent palsy), 26 of which resolved within 6 months of trauma. 23.5% underwent surgery, and 76.5% were conservatively managed. Surgeries targeted hematomas, hydrocephalus, or craniocervical instability. Approaches to hematomas included transclival and far/extreme lateral suboccipital approaches. Clinical outcome was good in 75.4% and intermediate or poor in 24.6%. Logistic regression suggested an association between craniocervical junction injuries and poor or intermediate outcomes (OR 4.88, 95% CI (1.17, 27.19), p = 0.04). CONCLUSION: Pediatric RCHs are mostly traumatic and extradural. Children between 5 and 9 years old are most vulnerable. Craniocervical junction injuries, mainly ligamentous, are common in RCHs and are associated with intermediate or poor outcomes. Cervical MRI could be important in cases of trauma to rule out ligamentous injuries of the craniocervical junction. The small size of RCHs should not exempt the careful assessment of craniocervical junction instability. Cranial nerve palsies are common and usually resolve within 6 months. Conservative treatment is typical unless brainstem compression, hydrocephalus, or craniocervical junction instability exists.

Spontaneous thrombosis of vein of Galen malformation managed with surgical resection: a case­based review.

INTRODUCTION: Vein of Galen malformation (VOGM) is an exceptionally uncommon form of congenital intracranial vascular malformations. It is highly unusual for this lesion to spontaneously thrombose. The clinical presentation of a patient may range from being asymptomatic to critically ill. The underlying pathophysiological mechanisms that cause spontaneous thrombosis are still poorly understood. METHODS AND RESULTS: The literature on spontaneous thrombosis of VOGM was systematically reviewed, analyzed, and summarized with a focus on its pathophysiology, types, clinical presentations, diagnosis, management, and outcomes. It was also illustrated with a case presentation. The case presents an unusual presentation and location of a VOGM in a 2-year-old boy who was successfully treated with surgical resection. CONCLUSIONS: A handful of cases of thrombosed VOGM have been reported worldwide where surgery was used to treat the condition. Low-flow fistulas of the mural type are prone to spontaneous thrombosis, have delayed clinical presentations, and are typically diagnosed in young children. Among the many possible manifestations, hydrocephalus is by far the most common. In the absence of blood flow, MRI is the diagnostic test of choice. Depending on the patient's symptoms, surgery to either remove the aneurysm or divert the cerebrospinal fluid usually results in a good prognosis.

Management of Low Back Pain in Primary Health-Care Settings: Physician's Awareness and Practices Based on Red Flags.

Background: Low back pain (LBP) is one of the most common health problems. Red flags (RFs) of LBP are risk factors that are reported during clinical assessment to determine serious illness. This study aimed to assess primary health-care physicians' knowledge of and practices for RFs of LBP and identify variables associated with a high level of knowledge and awareness about it. Methods: An observational cross-sectional survey was conducted in 2021 among a random sample of 261 primary health care (PHC) physicians in the Jazan Region in southwest Saudi Arabia. A web-based questionnaire was used to collect data on LBP red flags awareness and practices. Descriptive (frequency and percentage) and inferential statistics were used for data analysis. Results: The overall mean score of RFs knowledge among physicians was 82.33 ± 36.3, with 95% confidence interval (CI); (77.7-86.9). Regarding the Physician's practices, more than 95% of the participants would refer patients to higher levels in the presence of symptoms or signs of RFs. General practitioners and residents were significantly more likely to ask for an Xray, even with symptoms that had persisted for less than 2 weeks without RF signs (p = 0.006). The overall percentage of patients with nonspecific LBP referrals was as high as 57.8%. The number of patients with LBP seen per month (fewer than 15) and female physician were associated with an increased level of knowledge (OR = 2.2, 95%, P < 0.05) and (OR = 2.2, 95%, P < 0.05) respectively. Conclusion: Overall, awareness of RFs for LBP and referring critical patients who present with LBP is good among PHC physicians in the Jazan Region. Junior physicians have a low threshold to request images. The referral rate for nonspecific LBP is still high, which could overwhelm spinal clinics. Further educational programs for back pain management are recommended.

Isolated post-traumatic astereognosis: a case-based review.

INTRODUCTION: Astereognosis is the tactile inability to recognize objects placed in the palms by touch with the eyes closed or blind-folded in the presence of intact primary sensory modalities. Stereognosis is usually considered a function of the contralateral sensory cerebral cortex. However, lesions of several anatomic areas and pathologic entities have been reported to be associated with astereognosis. Only two previous reports linked traumatic injury to isolated astereognosis: following surgical evacuation of traumatic parietal extradural hematoma and following bullet injury in the neck in 1992 and 1919, respectively. METHODS AND RESULTS: All the pertinent literature was analyzed, focusing on the relevant definitions, clinical spectra, pathoanatomical processes, assessment, management, and outcomes of astereognosis. Also, an illustrative case was presented. The case highlights isolated post-traumatic left hand astereognosis in a 17-year-old boy following a blunt trauma to the head which resulted in a non-hemorrhagic contusion of the right post-central gyrus. CONCLUSIONS: Post-traumatic isolated astereognosis is a rare and probably underreported sequel of traumatic brain injury. Neurosurgeons need to be more sensitive to the assessment and detection of subtle stereognostic deficits in general and in trauma patients in particular. Other anatomical areas, in addition to the contralateral post-central gyrus, may be considered in the pathogenesis of astereognosis with the involvement of the dorsal column medial lemniscus tract such as the brainstem, foramen magnum, and the cervical spinal cord. To the best of our knowledge, this rare case report is considered the second report on astereognosis following head trauma, and the third report on astereognosis following trauma in general.

The STAR/HOP system: a newly proposed abbreviated descriptive clinical coding system for craniopharyngiomas.

Craniopharyngiomas are complex and challenging tumors of the central nervous system (CNS) which require multidisciplinary and tailored management plans. An extensive variety of clinical presentations, treatment options, and patient outcomes exists. It is crucial to accurately and effectively distinguish the clinical status and the patient's specific roadmap to ensure proper disease status identification, patient-tailored care, follow-up, doctor-doctor and doctor-patient communication, and research. The author proposes the four-tier STAR/HOP craniopharyngioma clinical coding system to facilitate case definitions, adequate reporting, and sound communication among neurosurgeons and other healthcare professionals. The new system utilizes symbols and conventions encompassing simple numerical tentative rules and relevant clinical concerning the tumor surgeries, adjuvant therapies, shunt systems, and access Ommaya devices with flexibility in giving extra information of shunt and Ommaya functionality, timing of radiation therapy, and different grades of tumor excision and recurrences as well. The HOP component provides a broad, yet simple description of hypothalamic, ophthalmological, and pituitary functions which are crucial to assess in each craniopharyngioma patient. Such a system could represent a new template for new clinical coding systems for brain tumors in general, and craniopharyngiomas in particular, and may eventually affect the World Health Organization (WHO) classification of brain tumors at some point. The system is easy to grasp, clinically practical, simple, and easy to communicate.

Benefits of endoscope-assisted microsurgery in the management of pediatric brain tumors.

OBJECTIVE: Microsurgical and endoscopic techniques are vastly utilized in brain tumor surgery. Combining both techniques in the same procedure has different forms and applications. The aim of this work was to discuss the usefulness and describe the technical benefits of endoscope-assisted microsurgery (EAMS) in treating pediatric brain tumors in various anatomical locations. METHODS: The medical records of 106 children who had undergone EAMS for brain tumors at Children's Cancer Hospital Egypt (CCHE-57357) between January 2009 and January 2017 were reviewed. The patients' ages ranged from 1 to 16 years (mean age 7.5 years). Technical variations, difficulties, complications, strategies, and extent of resection were addressed according to anatomical location. RESULTS: In general, EAMS enabled closer inspection of tumor extension and surrounding vital structures, especially in the hidden corners not appreciable by the microscope alone, such as tumors in the internal auditory canal and cerebellopontine angle contents in 14 cases, all of which were totally excised, and the undersurface of the optic apparatus in 65 craniopharyngiomas. Total excision was achievable in 51 of the 65 craniopharyngiomas; residual tumor was intentionally left behind under endoscopic guidance in the remaining 14 patients to ensure better hypothalamic function. Vision improved in 15 of 16 patients who initially presented with visual defects. Only 4 patients had new-onset postoperative endocrinopathies. For intraventricular tumors, EAMS allowed earlier recognition of tumor pedicle and, hence, earlier control of the blood supply of the tumor and safer total excision of 12 lateral ventricle, 6 pineal and third ventricle, and 9 fourth ventricle tumors. The tandem use of the endoscope and microscope enabled safer tumor dissections that were performed with more confidence in situations in which pure microscopic excision was either not achievable or less safe. Technical strategies, pitfalls, difficulties, and precautions were categorized and described per tumor location. CONCLUSIONS: EAMS of pediatric brain tumors is a promising, user-friendly tool that complements microsurgery in the management of these complex lesions. The benefits of 2D endoscopy are added to the benefits of stereoscopic perception. EAMS is especially helpful during the removal of different complex pediatric brain tumors. Simultaneous or tandem endoscopic and microscopic approaches may have the potential for better functional outcomes through better visualization and preservation of vital structures in corners that are hidden from the microscope.

Management of pediatric craniopharyngioma: 10-year experience from high-flow center.

PURPOSE: To report our experience and management strategies during 10 years for 137 childhood craniopharyngiomas treated at a single institution. METHODS: Medical records of children with craniopharyngioma treated at Children's Cancer Hospital Egypt (CCHE-57357) from July 2007 to December 2017 were retrospectively reviewed. Beta-catenin as an immunohistochemical marker was assessed also in available specimens. RESULTS: Our registry included 137 patients. Headache (n = 122), visual failure (n = 118), and hypothyroidism(n = 78) were the most common findings on presentation. Three management protocols were identified; 65 patients were primarily followed up after surgery, 71 patients had radiotherapy after surgery, and one patient underwent surgery for Ommaya insertion with intracystic interferon injection. Overall, gross total resection/near total resection was achieved in 48 cases (35.04%), subtotal resection was achieved in 58 patients (42.33%), 29 (21.16%) had biopsy and Ommaya reservoir, and two patients with calcified lesions had no operations. Fifty-four patients showed recurrence/progression of their lesions. Allover, 5-year progression-free survival (PFS) was 52.3%, while it was 34.49% and 72.25% for the follow-up group and the radiotherapy group, respectively. Beta-catenin mutations were positive in 61/95 patients; 5-year PFS for beta-catenin negative and positive cases was 65.5% and 39.4% respectively (p = 0.087). Mortality was reported in eight patients. Intraoperative endoscopy-assisted assessment was the cornerstone of tailored decision-making. CONCLUSION: The concepts of conservative surgery and multimodal management should be applied to reach the perfect balance between the quality of life and the best tumor control rates. Beta-catenin mutations more than 5% are associated with statistically trending aggressive clinical behavior. The CCHE-57357 algorithm of individualized management protocol was presented.

Frameless stereotaxy: It is all about precision.

BACKGROUND: Modern neurosurgery is nowadays based on technological advances. Intra-operative image guidance systems are frequently utilized in the everyday neurosurgical practice. Frameless stereotactic procedures (FSPs) require a great deal of technical abilities and precautions. Frameless stereotaxy mandates a high degree of problem-solving attitude and on-the-spot neurosurgeon's creativity. OBJECTIVE: In these technical notes, the author aims at presenting his experience in frameless stereotaxy for more than 10 years in the form of easily digestible tricks and pitfalls during every step of FSPs. METHODS: The author retrospectively distilled the tricks and pitfalls of the FSPs performed by him during the past 10 years according to their chronological status in a how-I-do-it fashion. RESULTS: Chronologically speaking, phases relating to any FSP were divided into five phases: (1) preoperative image acquisition, (2) pre-operative planning, (3) machine setup, positioning, and registration; (4) operative techniques; and (5) post-operative precautions. Faults in any of these phases can result in failure of the procedure or in faulty surgery with subsequent complications. Each stage is addressed in a how I do it fashion, questions and answers, bulleted or numbered tricks and pitfalls, and, in some instances, what-to-do-if scenarios were given. CONCLUSION: Frameless stereotaxy is a well-established neurosurgical practice. Many neurosurgeons are only aware with the bare minimum of the technical aspects of frameless stereotaxy and, subsequently, they practice the bare minimum of its applications. FSPs entail a great deal of technical tricks and pitfalls. Awareness of these techniques should be the target of every neurosurgeon.

A novel method for safe and accurate placement of the rocker pins of head immobilization devices utilizing a digital caliber phantom: technical note.

BACKGROUND: Immobilization of the head and skull by head immobilization devices (HIDs) is a common practice in neurosurgery. A variety of complications and morbidities are associated with pinning the skull during application of HIDs. OBJECTIVE: Our aim is to describe a new technique that avoids repeated puncturing of the head and skull during application of HIDs and hence avoiding the potential complications resulting from multiple re-adjustments. METHODS: We used a pre-adjusted digital millimetric caliber (DMC) as a phantom for the two rocker pins of the HID to mimic and simulate the process of skull pinning. Localization and preparation of the accurate skull pinning sites are safely guided by the pinning phantom. RESULTS: The technique was applied in different neurosurgical approaches. The pinning phantom was utilized to accurately locate the suitable pinning sites. Contrary to the common practice, there was no need for repeated head and skull puncturing. Minimal manipulations of the head and neck are exerted in this approach as compared with the usual techniques. The head of the patient is allowed to be kept safe on the operating table until the final one-time confident skull pinning by the sterilized skull clamp pins. CONCLUSION: The process of scalp and skull pinning of HIDs is technically demanding. The DMC utilized as a pinning phantom is a useful technique which provides safe and confident application of the skull rocker pins of HIDs allowing the neurosurgeon to avoid multiple puncturing of scalp and skull and minimizing manipulations of the head and cervical spine.

Management of pediatric CNS meningiomas: CCHE-57357 experience in 39 cases.

PURPOSE: Our aim is to present our experience in the management of pediatric meningiomas in the largest referral center in Egypt for pediatric tumors focusing on variables including clinical picture, anatomic location, histopathology, treatment strategies, and outcome together with their possible correlation to prognosis. METHODS: We retrospectively reviewed the medical records of 39 pediatric patients who were treated for CNS meningiomas in Children's Cancer Hospital-Egypt (CCHE-57357) 2007-2017. RESULTS: The prevalence of pediatric meningioma was 1.42%. Four cases had type 2 neurofibromatosis (NFII). The mean age was 8.19 years. The presence of NFII was associated with challenging multiple lesions, older age of presentation and poorer prognosis and functional outcome. Convexity was the commonest location. Gross total resection (GTR) was achieved in 28 cases, subtotal resection (STR) in 8 cases, and biopsy was decided in 3 patients. Histopathological examination revealed WHO grade I in 16 patients and higher grades in 23 patients (59%). The 5-year overall survival (OS) rate was 87.8% while the 5-years event-free survival (EFS) rate was 85.6%. Tumor location, histopathology, and clinical presentation were not statistically correlated to prognosis. CONCLUSIONS: Pediatric CNS meningiomas are uncommon pediatric tumors but of an aggressive clinical and pathological behaviors as compared to adult meningiomas. The presence of NFII is associated with a poorer prognosis and functional outcomes. Although being challenging, the maximum and safe surgical excision should be exercised even in recurrent cases in order to achieve the best outcome. Adjuvant radiotherapy provides good tumor control for inoperable residual atypical or anaplastic meningiomas.

Surgical and clinical aspects of cerebellar pilomyxoid-spectrum astrocytomas in children.

BACKGROUND: Cerebellar pilomyxoid astrocytomas (PMAs) and intermediate pilomyxoid astrocytomas (IPAs) are collectively called "pilomyxoid-spectrum astrocytomas (PMSAs)." Cerebellar PMSAs are thought to behave more aggressively than pilocytic astrocytomas (PAs). Our objective is to compare PMSAs to PAs in terms of surgical and clinical profiles. METHODS: This retrospective study included 66 cases (35 males and 31 females) with cerebellar astrocytomas treated between July 2007 and December 2012 at Children's Cancer Hospital Egypt (CCHE 57357) with a mean age of 7 (±1.5) years. Cases were divided into three subgroups as follows: 44 PAs, 10 IPAs, and 12 PMAs. Comparison between all groups was focusing on brain stem invasion, intrinsic necrotic cavitation, extent of resection, recurrence, leptomeningeal dissemination (LD), metastases, need for CSF diversion, and cerebellar mutism (CM). RESULTS: Cerebellar PMAs and IPAs separately and collectively had higher incidence of brain stem invasion, intrinsic necrotic cavitation, tumor recurrence, and LD when compared to PAs (P < 0.001). Gross total resection was 13.6 % in PMSAs versus 90.9 % in PAs (P < 0.001). PMAs had a higher incidence of tumor recurrence than IPAs (66.7 versus 20 %, P < 0.001). Incidence of recurrence in PAs was 9.1 % in partially resected cases. Mean interval to recurrence was 9 (±1.5) months in PMSAs and 42 (±2) months in PAs. CONCLUSIONS: Cerebellar PMSAs express an aggressive clinical behavior and impose more operative challenges than PAs. These tumors may represent a clinical spectrum-at its benign end lies PA, while PMA lies at the aggressive end, with IPA lying just behind. Such concepts could be used to guide management in the future.

The benefits of navigated intraoperative ultrasonography during resection of fourth ventricular tumors in children.

BACKGROUND: Safe and radical excision of pediatric fourth ventricular tumors is by far the best line of management. Pediatric fourth ventricular tumor surgery is a challenge for neurosurgeons. The aim of the study is to present the authors' experience and to evaluate the possible benefits of neuro-navigated intraoperative ultrasonography (NIOUS) during the surgery of fourth ventricular tumors in children. METHODS: Nonrandomized clinical trial study was conducted on 60 children with fourth ventricular tumors who were treated at Children's Cancer Hospital-Egypt. Mean age was 5.2 (±2.6) years. Thirty cases were operated upon utilizing the conventional microneurosurgical techniques. Another 30 cases were operated upon utilizing the NIOUS technique. RESULTS: Total tumor excision was achieved in 29 cases (96.7%) of NIOUS group versus 24 cases (80%) in the conventional group. Mean operative time NIOUS group was 150 min [standard deviation (SD) = 18.28) versus 140.6 min (SD = 18.6) in the conventional group (p value = 0.055). The mean operative blood loss was 67.5 ml (SD = 17) in NIOUS group versus 71 ml (SD = 15.4) in the conventional group. Postoperative cerebellar mutism occurred in one case (3.3%) of NIOUS group versus in six cases (20%) of the conventional group. CONCLUSIONS: Integration of navigated intraoperative ultrasonography in surgery of pediatric fourth ventricular tumors is a useful technology. It safely monitors maximum stepwise tumor excision. It is associated with less operative morbidity without significantly added operative time. It is a real-time, cost-effective, easily applicable, and easily interpretable tool that could substitute the use of intraoperative MRI especially in pediatric neurosurgery.